2. Signaling Pathways
  3. PROTAC
  4. Ligands for E3 Ligase
  5. MDM2 Isoform

MDM2

 

MDM2 Related Products (9):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0004
    Oridonin 28957-04-2 99.89%
    Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
    Oridonin
  • HY-130684
    MDM2 ligand 5 1410737-09-5 98.02%
    MDM2 ligand 5 is a Ligand for E3 Ligase that can be used for the synthesis of PROTACs.
    MDM2 ligand 5
  • HY-128837
    Nutlin carboxylic acid 2249750-27-2 98.63%
    Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC.
    Nutlin carboxylic acid
  • HY-128836
    (4R,5S)-Nutlin carboxylic acid 2306390-08-7
    (4R,5S)-Nutlin carboxylic acid is a MDM2 ligand and also a nutlin-3 derivative. (4R,5S)-Nutlin carboxylic acid can be linked to target protein ligands via a linker to form a PROTAC that can be used for targeting PARP1.
    (4R,5S)-Nutlin carboxylic acid
  • HY-P5930
    HOXB7 8–25
    HOXB7 8–25 (MDM2 32-46) is an MDM2-derived peptide epitope and can elicit antigen-specifc and tumor-reactive CD4+ T cell responses.
    HOXB7 8–25
  • HY-128837A
    (rel)-Nutlin carboxylic acid 2760669-71-2
    (rel)-Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. (rel)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC.
    (rel)-Nutlin carboxylic acid
  • HY-148106
    MEL23 642072-49-9
    MEL23 is a MDM2 E3 ligase inhibitor that blocks the E3 ligase activity of the MDM2-MDMX complex. MEL23 inhibits Mdm2 and p53 ubiquitination in cells, reduce viability of cells with wild-type p53. MEL23 stabilizes MDM2 via a mechanism independent of p53 transcription.
    MEL23
  • HY-168280
    AS1411-C4-VH032
    AS1411-C4-VH032 (AS1411-VH032) promotes tumor-selective degradation of MDM2, leading to tumor shrinkage without detectable toxicity.
    AS1411-C4-VH032
  • HY-181813
    PROTAC DHFR Degrader-1 3077918-47-6
    PROTAC DHFR Degrader-1 is a selective PROTAC degrader targeting Plasmodium falciparum DHFR-TS with a Ki of 2.01 nM. PROTAC DHFR Degrader-1 exhibits no inhibitory activity against human DHFR and suppresses the growth of Plasmodium falciparum. PROTAC DHFR Degrader-1 can be used for the research of Plasmodium falciparum and malaria.
    PROTAC DHFR Degrader-1